@article{ref1,
title="Phenytoin intoxication and serum level",
journal="Psychiatrie, Neurologie, und Medizinische Psychologie",
year="1978",
author="Beier, R. and Zschiesche, M. and Cammann, R.",
volume="30",
number="7",
pages="414-423",
abstract="The symptomatology of phenytoin intoxication was observed in 8.4% of 225 adult patients and in 9.5% of 74 children, with symptoms of cerebellar affection being noted in the majority of cases. Phenytoin concentrations were found to lie between 14.4 and 77.7 microgram/ml. Interindividual differences as to the toxic limit were quite considerable: One third of the patients showing values higher than 20 microgram/ml were free of striking clinical symptoms, and one patient tolerated a serum concentration in excess of 30 microgram/ml. On the other hand, the intraindividual toxic limit did not show any major variations: The clinical symptomatology of a patient correlated with his phenytoin serum concentration. After phenytoin withdrawal, the serum concentration dropped exponentially. The half-life periods of elimination were found to be between 72 and 122 hours.<p /><p>Language: de</p>",
language="de",
issn="0033-2739",
doi="",
url="http://dx.doi.org/"
}