@article{ref1,
title="Dose-dependent impairment in the performance of a go-no go successive discrimination by chlordiazepoxide",
journal="Psychopharmacology",
year="1986",
author="Cole, S. O. and Michaleski, A.",
volume="88",
number="2",
pages="184-186",
abstract="After learning a light-cued, go-no go successive discrimination to criterion, male Sprague-Dawley rats received 0, 5, or 10 mg/kg chlordiazepoxide on six performance sessions, followed by two drug-recovery (saline) sessions. Chlordiazepoxide impaired discrimination performance in a dose-dependent manner, with animals in the 5 mg/kg dose condition demonstrating tolerance to the drug after two performance sessions. The degree of discrimination impairment in both drug dose conditions paralleled an increase in responding during no-go phases of the performance task. These findings are consistent with a &quot;disinhibitory hypothesis&quot; of performance impairment and suggest that CDP-drugged animals have difficulty in withholding incorrect responses.<p /><p>Language: en</p>",
language="en",
issn="0033-3158",
doi="",
url="http://dx.doi.org/"
}