@article{ref1,
title="The ethics of randomized clinical trials",
journal="American journal of medicine",
year="1987",
author="Rosner, F.",
volume="82",
number="2",
pages="283-290",
abstract="Randomized clinical trials pose a number of fundamental ethical problems to which morally sensitive investigators must give careful consideration. The randomized double-blind clinical trial is ethically justified and the preferred method of demonstrating therapeutic effectiveness and safety. Alternate methods such as crossover and self-controlled designs, the use of historical controls, observational methods, and practitioner's clinical trials also exist and have their place in certain circumstances. The use of randomized double-blind clinical trials must assure adequate explanation of the research plan to the patient, the documentation of informed consent, adequate consideration of safety, and an acceptably low risk/benefit ratio.<p /><p>Language: en</p>",
language="en",
issn="0002-9343",
doi="",
url="http://dx.doi.org/"
}