@article{ref1,
title="Association between serum malondialdehyde levels and mortality in patients with severe brain trauma injury",
journal="Journal of neurotrauma",
year="2014",
author="Lorente, Leonardo and Martín, María M. and Abreu-González, Pedro and Ramos, Luis and Argueso, Mónica and Cáceres, Juan J. and Solé-Violán, Jordi and Lorenzo, José M. and Molina, Ismael and Jiménez, Alejandro",
volume="32",
number="1",
pages="1-6",
abstract="There is a hyperoxidative state in patients with trauma brain injury (TBI). Malondialdehyde (MDA) is an end-product formed during oxidative stress, concretely lipid peroxidation. In small studies (highest sample size 50 patients), higher levels of MDA have been found in non-surviving than surviving TBI patients. However, an association between serum MDA levels and mortality in patients with TBI has not been reported. Thus, the objective of this prospective, observational, multicenter study, carried out in six Spanish Intensive Care Units, was to determine whether MDA serum levels are associated with early mortality in a large series of patients with severe TBI. Serum MDA levels were measured in 100 patients with severe TBI on day 1 and in 75 healthy controls. The end-point of the study was 30-day mortality. We found higher serum MDA levels in patients with severe TBI than in healthy controls (P<0.001). Non-surviving TBI patients (N=27) showed higher serum MDA levels (P<0.001) than survivors (N=73). Logistic regression analysis showed that serum MDA levels were associated with 30-day mortality (OR=4.662; 95% CI=1.466-14.824; P=0.01), controlling for Glasgow coma score, age and computed tomography findings. Survival analysis showed that patients with serum MDA levels higher than 1.96 nmol/mL presented increased 30-day mortality than patients with lower levels (Hazard ratio=3.5; 95% CI=1.43-8.47; P<0.001). Thus, the most relevant new finding of our study, the largest to date on serum MDA levels in patients with severe TBI, was an association between serum MDA levels and early mortality.<p /> <p>Language: en</p>",
language="en",
issn="0897-7151",
doi="10.1089/neu.2014.3456",
url="http://dx.doi.org/10.1089/neu.2014.3456"
}