@article{ref1,
title="Promethazine, scopolamine and cinnarizine: comparative time course of psychological performance effects",
journal="Psychopharmacology",
year="1987",
author="Parrott, A. C. and Wesnes, K.",
volume="92",
number="4",
pages="513-519",
abstract="Single oral doses of promethazine (12.5 mg, 25 mg), scopolamine (0.6 mg), and cinnarizine (30 mg), were compared in a double-blind, placebo controlled trial. Twelve normal volunteers undertook a battery of psychological performance tests and a feeling state questionnaire, before drug administration, and at 2-h intervals after. Promethazine and cinnarizine significantly impaired psychomotor performance, information processing and feelings of alertness. With promethazine these reductions were maximal 3-4 h post-drug, with performance returning near to baseline 8-9 h post-drug. With cinnarizine these impairments were maximal 5-6 h post-drug, and performance remained depressed 8-9 h post-drug. Scopolamine significantly reduced feelings of alertness, and memory task performance; the overall performance effects were most evident 1-4 h post-drug.<p /><p>Language: en</p>",
language="en",
issn="0033-3158",
doi="",
url="http://dx.doi.org/"
}