@article{ref1,
title="Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy",
journal="CNS spectrums",
year="2014",
author="Morrissette, Debbi A. and Stahl, Stephen M.",
volume="19",
number="5",
pages="439-448",
abstract="Insufficient treatment of psychosis often manifests as violent and aggressive behaviors that are dangerous to the patient and others, and that warrant treatment strategies which are not considered first-line, evidence-based practices. Such treatment strategies include both antipsychotic polypharmacy (simultaneous use of 2 antipsychotics) and high-dose antipsychotic monotherapy. Here we discuss the hypothesized neurobiological substrates of various types of violence and aggression, as well as providing arguments for the use of antipsychotic polypharmacy and high-dose monotherapy to target dysfunctional neurocircuitry in the subpopulation of patients that is treatment-resistant, violent, and aggressive. In this review, we focus primarily on the data supporting the use of second-generation, atypical antipsychotics both at high doses and in combination with other antipsychotics.<p/> <p>Language: en</p>",
language="en",
issn="1092-8529",
doi="10.1017/S1092852914000388",
url="http://dx.doi.org/10.1017/S1092852914000388"
}