@article{ref1,
title="Reversal by caffeine of triazolam-induced impairment of waking function",
journal="Psychopharmacol Ser",
year="1988",
author="Roehrs, T. and Zwyghuizen-Doorenbos, A. and Smith, D. and Zorick, F. and Roth, T.",
volume="6",
number="",
pages="194-202",
abstract="Twelve, healthy normal men aged 21-25 years received each of four treatments (triazolam placebo plus caffeine placebo, triazolam 0.50 mg plus caffeine placebo, triazolam 0.50 mg plus caffeine 4 mg/kg, triazolam 0.50 mg plus caffeine 8 mg/kg), double blind, in a Latin-Square design. Triazolam or placebo was administered at 0830 and caffeine or placebo at 1000 and 1245. On two memory tasks, administered at 1015 with an immediate recall and a delayed recall at 1230 following a 90 min nap (1030-1200), both immediate and delayed recall was impaired by triazolam. Neither caffeine dose reversed the impairments. Sleep latency and sleep efficiency were improved by triazolam and not reversed by caffeine. On a performance battery presented at 1300 most measures of performance were impaired by triazolam; in general the caffeine dose of 4 mg/kg partially reversed the effect while the dose of 8 mg/kg completely restored performance.<p /><p>Language: en</p>",
language="en",
issn="0931-6795",
doi="",
url="http://dx.doi.org/"
}