@article{ref1,
title="Impact of hormonal prevention on fractures of the proximal femur in postmenopausal women: a simulation study",
journal="Sozial und Praventivmedizin",
year="1988",
author="Van der Loos, M. and Paccaud, F. and Gutzwiller, F. and Chrzanowski, R.",
volume="33",
number="3",
pages="162-166",
abstract="A simulation model of the effects of hormone replacement therapy (HRT) on hip fractures and their consequences is based on a population of 100,000 post-menopausal women. This cohort is confronted with literature derived probabilities of cancers (endometrium or breast, which are contra-indications to HRT), hip fracture, disability requiring nursing home or home care, and death. Administration of HRT for life prevents 55.5% of hip fractures, 22.6% of years with home care and 4.4% of years in nursing homes. If HRT is administered for 15 years, these results are 15.5%, 10% and 2.2%, respectively. A slight gain in life expectancy is observed for both durations of HRT. The net financial loss in the simulated population is 222 million Swiss Francs (cost/benefit ratio 1.25) for lifelong administration of HRT, and 153 million Swiss Francs (cost/benefit ratio 1.42) if HRT is administered during 15 years.<p /><p>Language: fr</p>",
language="fr",
issn="0303-8408",
doi="",
url="http://dx.doi.org/"
}