@article{ref1,
title="Paracetamol poisoning in a swine model",
journal="Z Exp Chir Transplant Kunstliche Organe",
year="1988",
author="Henne-Bruns, D. and Artwohl, J. and Dziwisch, L. and Kremer, B.",
volume="21",
number="5",
pages="255-263",
abstract="In order to prove the function of isolated transplanted hepatocytes in acute liver failure we tried to establish a hepatic failure model in pigs which correlates to a clinical situation. In 12 pigs we administered 500-2000 mg/kg body weight acetaminophen after enzyme induction with Pentobarbital. 7 animals receiving 500-1000 mg/kg acetaminophen survived the intoxication, 5 animals receiving 1000-2000 mg/kg acetaminophen died within 6.5 hours after intoxication because of methemoglobinemia. A close correlation between administered dosage of the drug, acetaminophen blood levels and methemoglobinemia was found. Histology of surviving animals showed a dosage depended cell necrosis. A standardized hepatic failure model could not be established in pigs by acetaminophen intoxication, because dosages of more than 1000 mg/kg were survived. In dosage higher than 1000 mg/kg a side effect of the acetaminophen intoxication the methemoglobinemia limited the life of the animals. Therefore acetaminophen can not be used to induce acute hepatic failure in pigs.<p /><p>Language: de</p>",
language="de",
issn="0232-7295",
doi="",
url="http://dx.doi.org/"
}