@article{ref1,
title="Are carbohydrate-deficient transferrin assays useful for the detection of recurrent 'binge drinking' in children with an alcohol intoxication in the emergency department?",
journal="Alcohol and alcoholism",
year="2014",
author="Stokbroekx, Margot A. L. and Houterman, Saskia and Coolen, Stefan A. J. and van der Lely, Nico and Pelleboer, Rolf A. A.",
volume="49",
number="6",
pages="635-638",
abstract="AIMS: The aim of this study was to evaluate different carbohydrate-deficient transferrin (CDT) assays for the detection of recurrent excessive alcohol abuse in adolescents prior to acute alcohol intoxication. <br><br>METHODS: Data on drinking behaviour and CDT levels of adolescents (13-18 years) registered at the outpatient clinic for youth and alcohol at three major district general hospitals in the Netherlands were retrospectively collected. CDT and disialotransferrin (DST) levels of binge-drinking teenagers were compared with non-binge-drinking teenagers. <br><br>RESULTS: In total 198 samples were collected for the N Latex CDT method (N = 83), no differences were found in mean CDT levels for binge versus non-binge drinkers (P = 0.8). The Helander HPLC (N = 78) showed significantly higher values for binge drinkers than for non-binge drinkers (mean 1.20%DST, SD 0.28 and mean 1.01%DST, SD 0.31, respectively (P = 0.01)). The Recipe ClinRep method (N = 37) also showed significantly higher values for binge drinkers (mean 1.17%DST, SD 0.36 and mean 0.89%DST, SD 0.34, respectively (P = 0.03)). <br><br>CONCLUSION: With the Helander HPLC method and the Recipe ClinRep assay higher levels are measured in binge drinkers than in non-binge drinkers.<p /> <p>Language: en</p>",
language="en",
issn="0735-0414",
doi="10.1093/alcalc/agu050",
url="http://dx.doi.org/10.1093/alcalc/agu050"
}