@article{ref1,
title="A predictive microsimulation model to estimate the clinical relevance of reducing alcohol consumption in alcohol dependence",
journal="European addiction research",
year="2014",
author="François, Clément and Laramée, Philippe and Rahhali, Nora and Chalem, Ylana and Aballéa, Samuel and Millier, Aurélie and Bineau, Sébastien and Toumi, Mondher and Rehm, Jürgen",
volume="20",
number="6",
pages="269-284",
abstract="BACKGROUND: Alcohol consumption is one of the most important factors for disease and disability in Europe. In clinical trials, nalmefene has resulted in a significant reduction in the number of heavy-drinking days (HDDs) per month and total alcohol consumption (TAC) among alcohol-dependent patients versus placebo. <br><br>METHODS: A microsimulation model was developed to estimate alcohol-attributable diseases and injuries in patients with alcohol dependence and to explore the clinical relevance of reducing alcohol consumption. <br><br>RESULTS: For all diseases and injuries considered, the number of events (inpatient episodes) increased with the number of HDDs and TAC per year. The model predicted that a reduction of 20 HDDs per year would result in 941 fewer alcohol-attributable events per 100,000 patients, while a reduction in intake of 3,000 g/year of pure alcohol (ethanol) would result in 1,325 fewer events per 100,000 patients. <br><br>CONCLUSION: The potential gains of reducing consumption in alcohol-dependent patients were considerable. © 2014 S. Karger AG, Basel.<p /> <p>Language: en</p>",
language="en",
issn="1022-6877",
doi="10.1159/000362408",
url="http://dx.doi.org/10.1159/000362408"
}