@article{ref1,
title="Modulating speed-accuracy strategies in major depression",
journal="Journal of psychiatric research",
year="2014",
author="Vallesi, Antonino and Canalaz, Francesca and Balestrieri, Matteo and Brambilla, Paolo",
volume="60",
number="",
pages="103-108",
abstract="BACKGROUND: Depression is associated with deficits in cognitive flexibility. The role of general slowing in modulating more specific cognitive deficits is however unclear. <br><br>AIM: We assessed how depression affects the capacity to strategically adapt behavior between harsh and prudent response modalities and how general and specific processes may contribute to performance deficits. <br><br>METHODS: Patients suffering from major depression and age- and education-matched healthy controls were asked to randomly stress either speed or accuracy during perceptual decision-making. <br><br>RESULTS: Diffusion models showed that patients with depression kept using a less conservative strategy after a trial with speed vs. accuracy instructions. Additionally, the depression group showed a slower rate of evidence accumulation as indicated by a generally lower drift rate. <br><br>CONCLUSIONS: These data demonstrate that less efficient strategic regulation of behavior in depression is due not only to general slowing, but also to more specific deficits, such as a rigid dependence on past contextual instructions. Future studies should investigate the neuro-anatomical basis of this deficit.<p /><p>Language: en</p>",
language="en",
issn="0022-3956",
doi="10.1016/j.jpsychires.2014.09.017",
url="http://dx.doi.org/10.1016/j.jpsychires.2014.09.017"
}