@article{ref1,
title="The role of excitatory amino acids and NMDA receptors in traumatic brain injury",
journal="Science",
year="1989",
author="Faden, Alan I. and Demediuk, P. and Panter, S. S. and Vink, R.",
volume="244",
number="4906",
pages="798-800",
abstract="Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with a reduction in cellular bioenergetic state and intracellular free magnesium. Treatment with the noncompetitive N-methyl-D-aspartate (NMDA) antagonist dextrophan or the competitive antagonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid limited the resultant neurological dysfunction; dextrorphan treatment also improved the bioenergetic state after trauma and increased the intracellular free magnesium. Thus, excitatory amino acids contribute to delayed tissue damage after brain trauma; NMDA antagonists may be of benefit in treating acute head injury.<p /><p>Language: en</p>",
language="en",
issn="0036-8075",
doi="",
url="http://dx.doi.org/"
}