@article{ref1,
title="A prospective naturalistic study of antidepressant-induced jitteriness/anxiety syndrome",
journal="Neuropsychiatric disease and treatment",
year="2014",
author="Harada, Tsuyoto and Inada, Ken and Yamada, Kazuo and Sakamoto, Kaoru and Ishigooka, Jun",
volume="10",
number="",
pages="2115-2121",
abstract="OBJECTIVE: Patients often develop neuropsychiatric symptoms such as anxiety and agitation after they have started taking an antidepressant, and this is thought to be associated with a potentially increased risk of suicide. However, the incidence of antidepressant-induced jitteriness/anxiety syndrome has not been fully investigated, and little has been reported on its predictors. The aim of this study was to survey the incidence of antidepressant-induced jitteriness/anxiety syndrome and clarify its predictors in a natural clinical setting. <br><br>MATERIALS AND METHODS: Between January 2009 and July 2012, we prospectively surveyed 301 patients who had not taken any antidepressants for 1 month before presentation, and who were prescribed antidepressants for 1 month after their initial visit. Patients were classified as developing antidepressant-induced jitteriness/anxiety syndrome if they experienced any symptoms of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, or mania during the first month. <br><br>RESULTS: Among the 301 patients, 21 (7.0%) developed antidepressant-induced jitteriness/anxiety syndrome. Major depressive disorder and a diagnosis of mood disorder in first-degree relatives of patients were significantly associated with induction of antidepressant-induced jitteriness/anxiety syndrome (odds ratio 10.2, P=0.001; odds ratio 4.65, P=0.02; respectively). However, there was no such relationship for sex, age, class of antidepressant, combined use of benzodiazepines, or diagnosis of anxiety disorder. <br><br>CONCLUSION: The findings of this study suggest that major depressive disorder and a diagnosis of mood disorder in first-degree relatives may be clinical predictors of antidepressant-induced jitteriness/anxiety syndrome.<p /> <p>Language: en</p>",
language="en",
issn="1176-6328",
doi="10.2147/NDT.S70637",
url="http://dx.doi.org/10.2147/NDT.S70637"
}