@article{ref1,
title="Spinal cord injury induces a long-lasting upregulation of interleukin-1β in astrocytes around the central canal",
journal="Neuroscience",
year="2014",
author="Paniagua-Torija, B. and Arevalo-Martin, A. and Molina-Holgado, E. and Molina-Holgado, F. and Garcia-Ovejero, D.",
volume="284C",
number="",
pages="283-289",
abstract="Under inflammatory conditions, interleukin-1β (IL-1β) modulates neural stem cells at neurogenic niches. Here we show that spinal cord injury in rats increases IL-1β expression in astrocytes located around the spinal cord ependyma, a region that also holds a neurogenic potential. IL-1β increases from day 1 after lesion, reaches maximal levels between days 3 and 7, and declines from 14days to low levels after 28days. At the time of maximal expression, periependymal upregulation of IL-1β extends beyond 5mm from the epicenter of the lesion both rostral and caudally. Since IL-1β controls proliferation and cell fate of neural stem/precursor cells, its modulation in periependymal astrocytes might create an appropriate environment for cell replacement after injury.<p /><p>Language: en</p>",
language="en",
issn="0306-4522",
doi="10.1016/j.neuroscience.2014.10.013",
url="http://dx.doi.org/10.1016/j.neuroscience.2014.10.013"
}