@article{ref1,
title="Transgenerational effects of binge drinking in a primate model: implications for human health",
journal="Fertility and sterility",
year="2014",
author="VandeVoort, Catherine A. and Grimsrud, Kristin N. and Midic, Uros and Mtango, Namdori and Latham, Keith E.",
volume="103",
number="2",
pages="560-569",
abstract="OBJECTIVE: To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development. <br><br>DESIGN: Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating. SETTING: National primate research center. ANIMAL(S): Adult female rhesus monkeys. INTERVENTION(S): Binge levels of ethanol, given twice weekly for 6 months before a standard in vitro fertilization cycle with or without embryo culture. With in vivo development, ethanol treatment continued until pregnancy was identified. MAIN OUTCOME MEASURE(S): Oocyte and cumulus/granulosa cell gene expression, embryo development to blastocyst, and pregnancy rate. RESULT(S): Embryo development in vitro was reduced; changes were found in oocyte and cumulus cell gene expression; and spontaneous abortion during very early gestation increased. <br><br>CONCLUSION(S): This study provides evidence that binge drinking can affect the developmental potential of oocytes even after alcohol consumption has ceased.<p /> <p>Language: en</p>",
language="en",
issn="0015-0282",
doi="10.1016/j.fertnstert.2014.10.051",
url="http://dx.doi.org/10.1016/j.fertnstert.2014.10.051"
}