@article{ref1,
title="Early-life cocaine interferes with BDNF-mediated behavioral plasticity",
journal="Learning and memory",
year="2014",
author="Hinton, Elizabeth A. and Wheeler, Marina G. and Gourley, Shannon L.",
volume="21",
number="5",
pages="253-257",
abstract="An important aspect of goal-directed action selection is differentiating between actions that are more or less likely to be reinforced. With repeated performance or psychostimulant exposure, however, actions can assume stimulus-elicited--or &quot;habitual&quot;--qualities that are resistant to change. We show that selective knockdown of prelimbic prefrontal cortical &quot;Brain-derived neurotrophic factor&quot; (&quot;Bdnf&quot;) increases sensitivity to response-outcome associations, blocking habit-like behavioral inflexibility. A history of adolescent cocaine exposure, however, occludes the &quot;beneficial&quot; effects of &quot;Bdnf&quot; knockdown. This finding highlights a challenge in treating addiction--that drugs of abuse may bias decision-making toward habit systems even in individuals with putative neurobiological resiliencies.<p /> <p>Language: en</p>",
language="en",
issn="1072-0502",
doi="10.1101/lm.033290.113",
url="http://dx.doi.org/10.1101/lm.033290.113"
}