@article{ref1,
title="Interactions between traumatic brain injury and frontotemporal degeneration",
journal="Dementia and geriatric cognitive disorders",
year="2014",
author="Deutsch, Mariel B. and Mendez, Mario F. and Teng, Edmond",
volume="39",
number="3-4",
pages="143-153",
abstract="BACKGROUND/AIMS: Prior work in smaller cohorts suggests that traumatic brain injury (TBI) may be a risk factor for frontotemporal degeneration (FTD). We sought to confirm and extend these results using the National Alzheimer's Coordinating Center Uniform Data Set. <br><br>METHODS: We compared the TBI prevalence between FTD subjects and matched normal controls. Indices of cognitive, behavioral, functional, and global dementia severity were compared between FTD subjects with and without prior TBI. <br><br>RESULTS: Remote TBI with extended loss of consciousness (TBI-ext) was more common in individuals with FTD than in controls (OR: 1.67; 95% CI: 1.004-2.778). With TBI-ext, less functional and global impairment was seen in the behavioral variant of FTD, but more behavioral pathology was seen in the semantic variant. <br><br>CONCLUSION: TBI may increase the FTD risk and influence clinical symptomatology and severity in FTD subtypes. © 2014 S. Karger AG, Basel.<p /> <p>Language: en</p>",
language="en",
issn="1420-8008",
doi="10.1159/000369787",
url="http://dx.doi.org/10.1159/000369787"
}