@article{ref1,
title="Comorbidity of affective disorders and alcohol use disorder",
journal="L'Encephale (1974)",
year="2014",
author="Pringuey, D. and Cherikh, F. and Lunacek, S. and Giordana, B. and Fakra, E. and Belzeaux, R. and Adida, Marc and Azorin, J-M",
volume="40",
number="Spec 3",
pages="S3-S7",
abstract="The comorbidity of affective disorders with alcohol use disorder remains insufficiently taken into account. In spite of the well-known frequency of the addict comorbidity in most psychiatric disorders, the level of association between affective disorders and alcohol is still underestimated and poorly understood. The label of &quot;double diagnosis&quot; relates to a simple addition of two independent pathologies. It is suggested to consider a &quot;dual psychopathology&quot; combining the effects of one disorder on the other. Interactions between the two disorders commit a complex state calling a new clinical reading, an adapted therapeutic strategy through a necessary integration of care. Association of alcohol use disorder and affective disorder, particularly in bipolar disorders, is correlated with severity, unstable course, treatment resistance and a greater risk of suicide. Alcohol aggravates depression and hampers therapeutics. Alcohol and mania remain a dreaded danger. The mechanism of the comorbid association does not only refer to a behavioral strategy of compensation but seems strongly based on a shared and crossed vulnerability, related to the genetics of the 5HT carrier and gene Clock. Therapeutic limitations do suggest the implementation of an &quot;integrated&quot; device which supposes a new organization of care and facilitation of collaborations between Addiction and Psychiatry.<p /> <p>Language: fr</p>",
language="fr",
issn="0013-7006",
doi="10.1016/S0013-7006(14)70123-X",
url="http://dx.doi.org/10.1016/S0013-7006(14)70123-X"
}