@article{ref1,
title="Parameters of bone health and fracture risk in older female fall victims: what do they tell us?",
journal="Zeitschrift fur Gerontologie",
year="2015",
author="Thaler, Heinrich W. and Oudshoorn, Christian and Hartholt, Klaas A. and van der Cammen, Tischa J. M.",
volume="48",
number="6",
pages="539-542",
abstract="INTRODUCTION: A common and severe osteoporotic type fracture in older women is a hip fracture. It is not clear whether bone turnover parameters measured in blood can be a useful tool to predict fracture risk in older persons. The aim of the current study was to assess the association between serum vitamin D (25OHD) levels, parathyroid hormone (PTH), total osteocalcin, carboxy-terminal collagen crosslinks (CTX) and hip fractures in older fallers. MATERIAL AND METHODS: A single centre, prospective cohort study of bone parameters was carried out in 400 female patients aged > 70 years including 200 with a hip fracture and 200 without fractures, admitted after a fall between January 2005 and December 2007. <br><br>RESULTS: Serum total osteocalcin levels were significantly lower in the fracture group compared to the non-fracture group (20.4 ng/ml vs 26.1 ng/ml, respectively, p = 0.01). This finding remained significant after exclusion of the patients on bisphosphonates (p = 0.003). There were no significant differences in 25OHD, PTH or CTX levels between the two groups. <br><br>CONCLUSION: In the current study there was an association between the presence of a hip fracture and lower total serum osteocalcin concentrations. This could be indicative of low bone turnover osteoporosis in these women. An association for other bone turnover markers was lacking.<p /> <p>Language: en</p>",
language="en",
issn="0044-281X",
doi="10.1007/s00391-014-0843-2",
url="http://dx.doi.org/10.1007/s00391-014-0843-2"
}