@article{ref1,
title="A meta-analysis of high dose, intermittent vitamin D supplementation among older adults",
journal="PLoS one",
year="2015",
author="Zheng, Ya Ting and Cui, Qi Qi and Hong, Yi Min and Yao, Wei Guang",
volume="10",
number="1",
pages="e0115850-e0115850",
abstract="BACKGROUND: The effects of intermittent, high dose vitamin D treatment in older adults have not been documented. We conducted a meta-analysis to provide a quantitative assessment of the efficiency of intermittent, high dose vitamin D treatment on falls, fractures, and mortality among older adults. <br><br>METHODS: Electronic databases were searched for randomized controlled trials (RCTs) on high dose, intermittent vitamin D supplementation among older adults. Two researchers independently screened the literature according to specified inclusive and exclusive criteria to extract the data. Meta-analysis was performed by using Review Manager 5.1.0 software. <br><br>RESULTS: Nine trials were included in this meta-analysis. High dose, intermittent vitamin D therapy did not decrease all-cause mortality among older adults. The risk ratio (95% CI) was 1.04 (0.91-1.17). No benefit was seen in fracture or fall prevention. The risk ratio for hip fractures (95% CI) was 1.17 (0.97-1.41) while for non-vertebral fractures (95% CI) it was 1.06 (0.91-1.22), and the risk ratio for falls (95% CI) was 1.02 (0.96-1.08). <br><br>RESULTS remained robust after sensitivity analysis. <br><br>CONCLUSION: Supplementation of intermittent, high dose vitamin D may not be effective in preventing overall mortality, fractures, or falls among older adults. The route of administration of vitamin D supplements may well change the physiological effects.<p /> <p>Language: en</p>",
language="en",
issn="1932-6203",
doi="10.1371/journal.pone.0115850",
url="http://dx.doi.org/10.1371/journal.pone.0115850"
}