@article{ref1,
title="Possible association between serotonin transporter gene polymorphism and suicide behavior in major depressive disorder",
journal="Psychiatry investigation",
year="2015",
author="Lee, Hwa-Young and Hong, Jin-Pyo and Hwang, Jung-A and Lee, Heon-Jeong and Yoon, Ho-Kyung and Lee, Bun-Hee and Kim, Yong-Ku",
volume="12",
number="1",
pages="136-141",
abstract="OBJECTIVE: The serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD). <br><br>METHODS: Serotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in 132 depressed patients with suicidal attempt as well as in 122 normal controls. Hamilton's 17-item Depression Rating Scale (HDRS), the Risk-Rescue rating system (RRR) and the Lethality Suicide Attempt Rating Scale updated (LSARS-II) were assessed for the depressed patients. <br><br>RESULTS: Although not statistically significant, a trend was found such that the 10/10 and 10/12 alleles of 5-HTTVNTR were more common in suicidal subjects than in control subjects. Comparing allele frequency, those with a 10 allele or 10 allele carriers were higher in suicidal subjects than in control subjects. No difference was noted in 5-HTTLPR genotypes and haplotype distribution between the suicidal subjects and control subjects. The RRR scores in subjects with the 10/10 5-HTTVNTR genotype or 10 5-HTTVNTR allele were significantly lower than those in subjects with other genotypes. <br><br>CONCLUSION: These results show the possibility that 10 allele of 5-HTTVNTR is related to suicidal behavior in the suicidal subjects with MDD and suggest that 12 allele of 5-HTTVNTR might be related to more lethality in the suicidal subjects with MDD.<p /> <p>Language: en</p>",
language="en",
issn="1738-3684",
doi="10.4306/pi.2015.12.1.136",
url="http://dx.doi.org/10.4306/pi.2015.12.1.136"
}