@article{ref1,
title="Adding fuel to the fire: the impact of stress on the ageing brain",
journal="Trends in neurosciences",
year="2015",
author="Prenderville, Jack A. and Kennedy, Paul J. and Dinan, Timothy G. and Cryan, John F.",
volume="38",
number="1",
pages="13-25",
abstract="Both ageing and chronic stress are associated with altered brain plasticity, dysregulation of the immune system, and an increased risk of developing brain disorders; all of which have consequences for cognitive and emotional processing. Here we examine the similarities between behavioural changes during ageing and stress altered behaviours (anxiety, depressive-like behaviour, cognition, and sociability) in rodents and humans. The molecular mechanisms hypothesised to mediate age-related changes in brain function including dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis, dysregulation of neurotransmission and neurotrophic factor signalling, increased inflammatory state, genetic and epigenetic changes, oxidative stress, metabolic changes, and changes in the microbiota-gut-brain axis are discussed. Finally, we explore how the already stressed aged brain psychologically and physiologically responds to external stressors.<p /> <p>Language: en</p>",
language="en",
issn="0166-2236",
doi="",
url="http://dx.doi.org/"
}