@article{ref1,
title="Ibuprofen-associated acute kidney injury in dehydrated children with acute gastroenteritis",
journal="Pediatric nephrology",
year="2015",
author="Balestracci, Alejandro and Ezquer, Mauricio and Elmo, María Eugenia and Molini, Andrea and Thorel, Claudia and Torrents, Milagros and Toledo, Ismael",
volume="30",
number="10",
pages="1873-1878",
abstract="BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) induce acute kidney injury (AKI) in volume-depleted patients; however the prevalence of this complication is likely underestimated. We assessed the impact of ibuprofen exposure on renal function among dehydrated children with acute gastroenteritis (AGE) to further characterize NSAID-associated AKI. <br><br>METHODS: Over a 1-year period dehydrated children with AGE (n = 105) were prospectively enrolled and grouped as cases, presenting with AKI (n = 46) or controls, not presenting with AKI (n = 59). AKI was defined by pediatric RIFLE (pRIFLE) criteria. <br><br>RESULTS: Among the children enrolled in the study, AKI prevalence was 44 %, and 34 (54 %) of the 63 patients who received ibuprofen developed renal impairment. Relative to the controls, children presenting with AKI were younger (median age 0.66 vs. 1.74 years; p < 0.001) and received ibuprofen more frequently (74 vs. 49 %, p = 0.01). After adjusting for the degree of dehydration, ibuprofen exposure remained an independent risk factor for AKI (p < 0.001, odds ratio 2.47, 95 % confidence interval 1.78-3.42). According to the pRIFLE criteria, 17 patients were at the 'risk' stage of AKI severity, 24 were at the 'injury' stage, and five were at the 'failure' stage; none required dialysis. Distribution of patients within categories was similar regardless of ibuprofen exposure. All cases fulled recovered from AKI. <br><br>CONCLUSIONS: Ibuprofen-associated AKI was 54 % in our cohort of dehydrated children with AGE. Drug exposure increased the risk for developing AKI by more than twofold, independent of the magnitude of the dehydration.<p /> <p>Language: en</p>",
language="en",
issn="0931-041X",
doi="10.1007/s00467-015-3105-7",
url="http://dx.doi.org/10.1007/s00467-015-3105-7"
}