@article{ref1,
title="Physical effort affects heatstroke thermoregulatory response and mortality in rats",
journal="Shock",
year="2015",
author="Geng, Yan and Peng, Na and Li, Xing-Gui and Liu, Ya-Nan and Li, Bing-Lin and Peng, Li-Qiong and Ma, Qiang and Su, Lei",
volume="44",
number="2",
pages="149-156",
abstract="Animals suffering from heatstroke (HS) following physical effort may have different heat-related core temperature (Tc) responses compared with passive HS. In the present study, conscious and unrestrained rats were exposed to ambient temperature (Ta) of 39.5 ± 0.2°C with or without running (run-heated or rest-heated, respectively) until HS onset, which was defined as the systolic blood pressure (SBP) starting to drop. In comparison with rest-heated rats, run-heated rats had a significantly shorter latency of HS onset. Physical effort did not have significant influence on hyperthermia severity (43.3±0.2°C at rest-heated, and 43.4±0.2°C at run-heated), but it could significantly decrease the thermal load to develop HS (315.1±37.3°C[BULLET OPERATOR]min for rest-heated, and 133.5±21.4°C[BULLET OPERATOR]min for run-heated). Working component during heat exposure may contribute to a decreased survival rate of HS (46.9% at rest-heated, and 31.3% at run-heated). Impaired heat dissipation during recovery may be the responsible for relative poor survival of run-heated rats. In both groups, survival was affected by Tc,HS and thermal area. Hypothermia (Tc <35°C) developed after HS onset, with no significant difference in Tc,min between the rest-heated and run-heated groups. These thermoregulatory responses to HS after physical effort may provide insight into HS pathophysiology.<p /> <p>Language: en</p>",
language="en",
issn="1073-2322",
doi="10.1097/SHK.0000000000000387",
url="http://dx.doi.org/10.1097/SHK.0000000000000387"
}