@article{ref1,
title="Benzodiazepine and nonbenzodiazepine hypnotics",
journal="Nippon Rinsho",
year="2015",
author="Nakamura, Masaki and Inoue, Yuichi",
volume="73",
number="6",
pages="1010-1015",
abstract="The prevalence of insomnia shows an age-associated increase. Especially, persons with age over 60 years frequently suffer from arousal during sleep and early-morning awakening. The reason of this phenomenon can be explained by age-related change in sleepwake regulation, comorbid diseases and psycho-social status. Benzodiazepine derivatives and benzodiazepine agonists have been widely used for treatment of insomnia. These GABA-A receptor agonist hypnotics have sedative effect, possibly causing various adverse events, i.e. falls and hip fracture, anterograde amnesia, next morning hangover especially in the elderly. When making a choice of treatment drugs for the elderly, low dose benzodiazepine hypnotics with relatively high Ω1-selectivity, and newer hypnotics including melatonic receptor agonist or orexin receptor antagonist can become important candidates considering their comorbid diseases or drug interaction with other medications.<p /> <p>Language: ja</p>",
language="ja",
issn="0047-1852",
doi="",
url="http://dx.doi.org/"
}