@article{ref1,
title="Neurotoxicity associated with exposure to 1-bromopropane in golf-club cleansing workers",
journal="Clinical toxicology (Philadelphia, Pa.)",
year="2015",
author="Wang, Te-Hao and Wu, Ming-Ling and Wu, Ya-Hsueh and Tsai, Wen-Jen and Lin, Kon-Ping and Wang, Chao-Lin and Yang, Chen-Chang and Deng, Jou-Fang",
volume="53",
number="8",
pages="823-826",
abstract="BACKGROUND: 1-Bromopropane (1-BP) is an alternative to ozone-depleting solvent that is used in degreasing, dry cleaning, spray adhesives, and aerosol solvents. Occupational exposure to 1-BP is associated with adverse peripheral sensory, motor, and central nervous system (CNS) effects. We report our Health Hazard and Medical Evaluation of 6 patients with neurotoxicity associated with occupational exposure to 1-BP. Case series and environmental evaluation. Six workers, 1 male and 5 female, were exposed to high ambient 1-BP concentrations while employed in a golf club cleaning factory. 1-BP was identified in the bulk solvent sample used by the workers and confirmed the workers' daily occupational exposure to 1-BP for 3-10 months. The major presenting symptoms were tingling pain, soreness in lower extremities, and paresthesia. N-acetyl-S-(n-propyl)-L-cysteine (AcPrCys), a 1-BP metabolite, was identified by LC/MS/MS in the urine (0.171-1.74 mg/g-Cr) of these workers 5-26 days following 1-BP exposure. <br><br>DISCUSSION AND CONCLUSION: An occupational outbreak of 1-BP poisoning occurred as a result of recurrent power outages, condenser, and exhaust fans malfunction, and inadequate personal protection. Occupational exposure to 1-BP may result in peripheral neuropathy as well as adverse CNS effects. Urine AcPrCys may be a specific biomarker for 1-BP exposure.<p /> <p>Language: en</p>",
language="en",
issn="1556-3650",
doi="10.3109/15563650.2015.1064939",
url="http://dx.doi.org/10.3109/15563650.2015.1064939"
}