@article{ref1,
title="Dissecting the cannabinergic control of behavior: the where matters",
journal="Bioessays",
year="2015",
author="Busquets-Garcia, Arnau and Desprez, Tifany and Metna-Laurent, Mathilde and Bellocchio, Luigi and Marsicano, Giovanni and Soria-Gomez, Edgar",
volume="37",
number="11",
pages="1215-1225",
abstract="The endocannabinoid system is the target of the main psychoactive component of the plant Cannabis sativa, the Δ(9) -tetrahydrocannabinol (THC). This system is composed by the cannabinoid receptors, the endogenous ligands, and the enzymes involved in their metabolic processes, which works both centrally and peripherally to regulate a plethora of physiological functions. This review aims at explaining how the site-specific actions of the endocannabinoid system impact on memory and feeding behavior through the cannabinoid receptors 1 (CB1 R). Centrally, CB1 R is widely distributed in many brain regions, different cell types (e.g. neuronal or glial cells) and intracellular compartments (e.g. mitochondria). Interestingly, cellular and molecular effects are differentially mediated by CB1 R according to their cell-type localization (e.g. glutamatergic or GABAergic neurons). Thus, understanding the cellular and subcellular function of CB1 R will provide new insights and aid the design of new compounds in cannabinoid-based medicine.<p /> <p>Language: en</p>",
language="en",
issn="0265-9247",
doi="10.1002/bies.201500046",
url="http://dx.doi.org/10.1002/bies.201500046"
}