@article{ref1,
title="Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb Polygonum multiflorum",
journal="Frontiers of medicine",
year="2015",
author="Wang, Jiabo and Ma, Zhijie and Niu, Ming and Zhu, Yun and Liang, Qingsheng and Zhao, Yanling and Song, Jingyuan and Bai, Zhaofang and Zhang, Yaming and Zhang, Ping and Li, Na and Meng, Yakun and Li, Qi and Qin, Lushan and Teng, Guangju and Cao, Junling and Li, Baosen and Chen, Shilin and Li, Yonggang and Zou, Zhengsheng and Zhou, Honghao and Xiao, Xiaohe",
volume="9",
number="4",
pages="457-467",
abstract="Herbal medicines have recently been recognized as the second most common cause of drug-induced liver injury (DILI) in the United States. However, reliable methods to identify the DILI causality of some herbs, such as Heshouwu (dried root of Polygonum multiflorum), remain lacking. In this study, a total of 12 307 inpatients with liver dysfunction and 147 literature-reported cases of Heshouwu DILI were screened. A general algorithm indicated that only 22.5% (9/40) and 30.6% (45/147) of all hospitalization and literature case reports, respectively, demonstrate the high probability of DILI causality of Heshouwu. By contrast, 95% (19/20) of all cases prospectively investigated by pharmacognosy, phytochemistry, and metabolomic tests exhibited highly probable causality, including a patient who was previously incorrectly attributed and a case that was excluded from Heshouwu causality by pharmacognostic evidence. Toxin (heavy metals, pesticides, and mycotoxins) contamination was also excluded from Heshouwu DILI causality. The objectivity of these screening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal medicines and dietary supplements.<p /> <p>Language: en</p>",
language="en",
issn="2095-0217",
doi="10.1007/s11684-015-0417-8",
url="http://dx.doi.org/10.1007/s11684-015-0417-8"
}