@article{ref1,
title="Association of brain-derived neurotrophic factor G196a and attempted suicide: a case-control study in rural China",
journal="Neuropsychobiology",
year="2015",
author="Wang, Jin-Yu and Wang, Xin-Ting and Wang, Lin-Lin and Jia, Cun-xian",
volume="72",
number="2",
pages="91-96",
abstract="BACKGROUND: Suicide is an important public problem, the mechanism of which has not been clarified. Many studies have focused on the molecular, biological and genetic mechanisms of suicide. Brain-derived neurotrophic factor (BDNF) G196A is one of the most leading loci in recent studies, but the results are inconsistent. <br><br>METHODS: We conducted a 1:1 age- and sex-matched case-control study in rural areas of Shandong Province, China. A total of 365 pairs of cases and controls were finally recruited into our study. The adjusted odds ratios (AORs) of BDNF 196G/G and their 95% confidence intervals (CIs) were calculated by multivariate conditional logistic regression models. <br><br>RESULTS: No association between BDNF polymorphisms and attempted suicide was found in the overall population. However, the BDNF 196G/G genotype was significantly related to attempted suicide in the elderly population (AOR = 7.85, 95% CI: 1.12-54.90, p = 0.038), while the associations were not significant in young and middle-aged groups. <br><br>CONCLUSION: Our study suggests that the BDNF 196G/G genotype increases the risk of attempted suicide in elderly people.<p /> <p>Language: en</p>",
language="en",
issn="0302-282X",
doi="10.1159/000439352",
url="http://dx.doi.org/10.1159/000439352"
}