@article{ref1,
title="Retrospective review of unintentional pediatric ingestions of doxylamine",
journal="Clinical toxicology (Philadelphia, Pa.)",
year="2015",
author="Cantrell, F. Lee and Qozi, Mariam and McKinley, Michael and Clark, Alycia K.",
volume="53",
number="3",
pages="178-180",
abstract="BACKGROUND. Doxylamine is a first-generation antihistamine similar in structure to diphenhydramine. Unlike diphenhydramine, however, there is a paucity of data regarding the risk of toxicity following unintentional exposures in pediatric patients. <br><br>METHODS. We performed an observational case series with data collected retrospectively from a poison system database for all single-substance pediatric (5 years-old and younger) doxylamine ingestions for the period of 1997-2012. Data collected included age, gender, weight, reason for exposure, exact or estimated maximum dose, clinical effects and medical interventions. <br><br>RESULTS. A total of 140 cases were identified; 74 (53%) involved males. Ages ranged 6 months to 5 years. In 30 cases (21%), the exact amount ingested was documented and ranged from 6.25-50 mg with a maximum weight-based dose of 6.2 mg/kg. In 76 cases, the estimated maximum dose ranged from 12.5 to 375 mg with a maximum weight-based dose of 37 mg/kg. All symptoms were mild and self-limiting. The only documented intervention was the administration of activated charcoal in 13 cases. <br><br>CONCLUSION. Unintentional isolated pediatric doxylamine ingestions did not result in significant toxicity in our 140 cases. Reported doses of up to 6.2 mg/kg resulted in only transient drowsiness and tachycardia.<p /> <p>Language: en</p>",
language="en",
issn="1556-3650",
doi="10.3109/15563650.2015.1006400",
url="http://dx.doi.org/10.3109/15563650.2015.1006400"
}