@article{ref1,
title="The cardiac injury effect of microwave radiation on rabbit and its mechanism",
journal="Wei Sheng Yan Jiu",
year="2015",
author="Zhu, Wenhe and Shen, Nan and Zhong, Xiuhong and Hou, Jianchen and Lü, Shijie and Cai, Jianhui",
volume="44",
number="5",
pages="818-821",
abstract="OBJECTIVE: To investigate the cardiac injury effect of different intensities microwave radiation on rabbits and its possible mechanism. <br><br>METHODS: Rabbits were radiated by intensity of 50, 100, 150 and 200 mW/cm2 2450 MHz microwave for 20 min. 6 h after microwave radiation, the heart tissue was taken. ATP and mitochondria complex IV and V were measured in myocardial cells. The changes of myocardial tissue were observed by light microscopic. The expression of Caspase-3 and HSP 70 were detected by western blotting. <br><br>RESULTS: The activity of ATP and mitochondria complex IV and V decreased significantly compared with normal control in cardiac tissue. 100, 150 and 200 mW/cm2 microwave radiation group vs. control group (P <0. 05). The HE staining result showed that myocardial cell appears edema, muscle fiber malalignment, cells appeared obvious injury. <br><br>RESULTS of western blotting showed that the expression of Caspase-3 and HSP 70 protein increased significantly in different dosage radiation group (P <0. 05). <br><br>CONCLUSION: Microwave radiation has injury effect on rabbit heart. The possible mechanism may be related with inducing cell apoptosis by changing of stress level in myocardial cell.<p /> <p>Language: zh</p>",
language="zh",
issn="1000-8020",
doi="",
url="http://dx.doi.org/"
}