@article{ref1,
title="Interaction of CD38 variant and chronic interpersonal stress prospectively predicts social anxiety and depression symptoms over 6 years",
journal="Clinical psychological science",
year="2016",
author="Tabak, Benjamin A. and Vrshek-Schallhorn, Suzanne and Zinbarg, Richard E. and Prenoveau, Jason M. and Mineka, Susan and Redei, Eva E. and Adam, Emma K. and Craske, Michelle G.",
volume="4",
number="1",
pages="17-27",
abstract="Variation in the CD38 gene, which regulates secretion of the neuropeptide oxytocin, has been associated with several social phenotypes. Specifically, rs3796863 A allele carriers have demonstrated increased social sensitivity. In 400 older adolescents, we used trait-state-occasion modeling to investigate how rs3796863 genotype, baseline ratings of chronic interpersonal stress, and their gene-environment (G×E) interaction predicted trait social anxiety and depression symptoms over 6 years. We found significant G×E effects for CD38 A-carrier genotypes and chronic interpersonal stress at baseline predicting greater social anxiety and depression symptoms. A significant G×E effect of smaller magnitude was also found for C/C genotype and chronic interpersonal stress predicting greater depression; however, this effect was small compared with the main effect of chronic interpersonal stress. Thus, in the context of chronic interpersonal stress, heightened social sensitivity associated with the rs3796863 A allele may prospectively predict risk for social anxiety and (to a lesser extent) depression.<p /> <p>Language: en</p>",
language="en",
issn="2167-7026",
doi="10.1177/2167702615577470",
url="http://dx.doi.org/10.1177/2167702615577470"
}