@article{ref1,
title="Antidepressant use and work-related injuries",
journal="Psychological medicine",
year="2016",
author="Kouvonen, A. and Vahtera, J. and Pentti, J. and Korhonen, M. J. and Oksanen, T. and Salo, P. and Virtanen, M. and Kivimäki, M.",
volume="46",
number="7",
pages="1391-1399",
abstract="BACKGROUND: Adverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use. <br><br>METHOD: Antidepressant use and work-related injuries between 2000 and 2011 were measured among 66 238 employees (mean age 43.8 years, 80% female) using linkage to national records (the Finnish Public Sector study). We analysed data using time-dependent modelling with individuals as their own controls (self-controlled case-series design). <br><br>RESULTS: In 2238 individuals who had used antidepressants and had a work-related injury during a mean follow-up of 7.8 years, no increase in the risk of injury was observed in the beginning of antidepressant treatment. However, an increased injury risk was seen after 3 months of treatment (rate ratio, compared with no recent antidepressant use, 1.27, 95% confidence interval 1.10-1.48). This was also the case among those who had used only selective serotonin reuptake inhibitors (n = 714; rate ratio 1.41, 95% confidence interval 1.08-1.83). <br><br>CONCLUSIONS: Antidepressant use was not associated with an increased risk of work-related injury at the beginning of treatment. Post-hoc analyses of antidepressant trials are needed to determine whether long-term use of antidepressants increases the risk of work-related injury.<p /> <p>Language: en</p>",
language="en",
issn="0033-2917",
doi="10.1017/S0033291715002925",
url="http://dx.doi.org/10.1017/S0033291715002925"
}