@article{ref1,
title="Adverse effects in children after unintentional buprenorphine exposure",
journal="Pediatrics",
year="2006",
author="Geib, Ann-Jeannette and Babu, Kavita and Ewald, Michele Burns and Boyer, Edward W.",
volume="118",
number="4",
pages="1746-1751",
abstract="Buprenorphine in sublingual formulation was recently introduced to the American market for treatment of opioid dependence. We report a series of 5 toddlers with respiratory and mental-status depression after unintentional buprenorphine exposure. Despite buprenorphine's partial agonist activity and ceiling effect on respiratory depression, all children required hospital admission and either opioid-antagonist therapy or mechanical ventilation. Results of routine urine toxicology screening for opioids were negative in all cases. Confirmatory testing was sent for 1 child and returned with a positive result. The increasing use of buprenorphine as a home-based therapy for opioid addiction in the United States raises public health concerns for the pediatric population.<p /> <p>Language: en</p>",
language="en",
issn="0031-4005",
doi="10.1542/peds.2006-0948",
url="http://dx.doi.org/10.1542/peds.2006-0948"
}