@article{ref1,
title="Drug-induced long QT syndrome increases the risk of drowning",
journal="Medical hypotheses",
year="2016",
author="Vincenzi, Frank F.",
volume="87",
number="",
pages="11-13",
abstract="There is strong evidence linking inherited long QT syndromes with an increased risk of drowning due to fatal arrhythmias in the water. Drug-induced long QT syndrome (DILQTS) is hypothesized to increase the risk of drowning by similar mechanisms. It is suggested that QT prolongation caused by a drug or drugs, when combined with the autonomic conflict associated with the mammalian dive reflex and/or the cold shock reflex, sets up conditions that may result in a sudden fatal arrhythmia while in water - thus an increased risk of drowning related to a drug-induced prolongation of the QT interval. Many widely used drugs prolong the QT interval thus raising a drug safety issue that needs confirmation or refutation.<p /> <p>Language: en</p>",
language="en",
issn="0306-9877",
doi="10.1016/j.mehy.2015.12.015",
url="http://dx.doi.org/10.1016/j.mehy.2015.12.015"
}