@article{ref1,
title="Hepatotoxicity by drugs: the most common implicated agents",
journal="International journal of molecular sciences",
year="2016",
author="Björnsson, Einar S.",
volume="17",
number="2",
pages="e17020224-e17020224",
abstract="Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analysis of the hepatotoxicity of drugs in LiverTox, 53% of drugs had at least one case report of convincing reports of liver injury. Only 48 drugs had more than 50 case reports of DILI. Amoxicillin-clavulanate is the most commonly implicated agent leading to DILI in the prospective series. In a recent prospective study, liver injury due to amoxicillin-clavulanate was found to occur in approximately one out of 2300 users. Drugs with the highest risk of DILI in this study were azathioprine and infliximab.<p /> <p>Language: en</p>",
language="en",
issn="1661-6596",
doi="10.3390/ijms17020224",
url="http://dx.doi.org/10.3390/ijms17020224"
}