@article{ref1,
title="The interactive effect of the MAOA-VNTR genotype and childhood abuse on aggressive behaviors in Chinese male adolescents",
journal="Psychiatric genetics",
year="2016",
author="Zhang, Yun and Ming, Qingsen and Wang, Xiang and Yao, Shuqiao",
volume="26",
number="3",
pages="117-123",
abstract="OBJECTIVE: Gene-environment interactions that moderate aggressive behavior have been identified in association with the MAOA (monoamine oxidase A) gene. The present study examined the moderating effect of MAOA-VNTR (variable number of tandem repeats) on aggression behavior relating to child abuse among Chinese adolescents. <br><br>MATERIALS AND METHODS: A sample of 507 healthy Chinese male adolescents completed the Child Trauma Questionnaire-Short Form (CTQ-SF) and Youth Self-report of the Child Behavior Checklist. The participants' buccal cells were sampled and subjected to DNA analysis. The effects of childhood abuse (CTQ-SF scores), MAOA-VNTR [high-activity allele (H) versus low-activity allele (L)], and their interaction in aggressive behaviors were analyzed by linear regression. <br><br>RESULTS: Child maltreatment was found to be a significant independent factor in the manifestation of aggressive behavior, whereas MAOA activity was not. There was a significant interaction between MAOA-VNTR and childhood maltreatment in the exhibition of aggressive behaviors. In the context of physical or emotional abuse, boys in the MAOA-L group showed a greater tendency toward aggression than those in the MAOA-H group. <br><br>CONCLUSION: Aggressive behavior arising from childhood maltreatment is moderated by MAOA-VNTR, which may be differentially sensitive to the subtype of childhood maltreatment experienced, among Chinese adolescents.<p /> <p>Language: en</p>",
language="en",
issn="0955-8829",
doi="10.1097/YPG.0000000000000125",
url="http://dx.doi.org/10.1097/YPG.0000000000000125"
}