@article{ref1,
title="Cigarette smoking and tryptophan hydroxylase 2 mRNA in the dorsal raphe nucleus in suicides",
journal="Archives of suicide research",
year="2016",
author="Bach, Helene and Arango, Victoria and Kassir, Suham A. and Dwork, Andrew J. and Mann, J. John and Underwood, Mark D.",
volume="20",
number="3",
pages="451-462",
abstract="Cigarette smoking is associated with suicide and mood disorders and stimulates serotonin release. Tryptophan hydroxylase (TPH2) synthesizes serotonin and is over-expressed in suicides. We determined whether smoking is associated with TPH2 mRNA in suicides and controls. TPH2 mRNA was measured postmortem in the dorsal raphe nucleus (DRN) of controls (N = 26, 17 nonsmokers and nine smokers) and suicides (N = 23, 5 nonsmokers and 18 smokers). Psychiatric history was obtained by psychological autopsy. TPH2 mRNA was greater in suicide nonsmokers than suicide smokers, control smokers and control nonsmokers (p = 0.006). There was more TPH2 mRNA throughout the DRN. Smoking interferes with the TPH2 mRNA increase observed in suicide nonsmokers. The absence of altered TPH2 expression in non-suicide smokers suggests no pharmacological effect of smoking.<p /> <p>Language: en</p>",
language="en",
issn="1381-1118",
doi="10.1080/13811118.2015.1048398",
url="http://dx.doi.org/10.1080/13811118.2015.1048398"
}