@article{ref1,
title="Intact neural activity during a Go/No-go task is associated with high global functioning in schizophrenia",
journal="Psychiatry and the Clinical Neurosciences",
year="2016",
author="Araki, Tsuyoshi and Kirihara, Kenji and Koshiyama, Daisuke and Nagai, Tatsuya and Tada, Mariko and Fukuda, Masato and Kasai, Kiyoto",
volume="70",
number="7",
pages="278-285",
abstract="AIM: Go/No-go derived event-related potential (ERP) signals have been widely used in schizophrenia research to monitor self-control deficits in this disorder. However, no study to date has associated Go/No-go related ERPs with global functioning. <br><br>METHODS: Participants consisted of 21 patients with schizophrenia and 22 healthy controls. We used a visual Go/No-go paradigm to measure Go/No-go-related N2/P3 ERP components by means of a 64-electrode cap for EEG recording. We used the Global Assessment of Functioning (GAF) to evaluate global functioning and analyzed the correlation between ERP indices and global functioning scores. <br><br>RESULTS: N2 amplitudes were reduced in patients with schizophrenia, but not influenced by either Go/No-go condition. P3 amplitudes were influenced by the Go/No-go conditions, but not reduced in patients with schizophrenia. Global functioning was correlated with the No-go P3 amplitudes, but not N2 amplitudes, in patients with schizophrenia. <br><br>CONCLUSION: These results indicate that global functioning is associated with intact neural activity rather than impaired neural activity during Go/No-go response inhibition tasks in patients with schizophrenia.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1323-1316",
doi="10.1111/pcn.12389",
url="http://dx.doi.org/10.1111/pcn.12389"
}