@article{ref1,
title="High serum adiponectin levels predict incident falls among middle-aged and older adults: a prospective cohort study",
journal="Age and ageing",
year="2016",
author="Huang, Cong and Momma, Haruki and Niu, Kaijun and Chujo, Masahiko and Otomo, Atsushi and Cui, Yufei and Nagatomi, Ryoichi",
volume="45",
number="3",
pages="366-371",
abstract="BACKGROUND AND OBJECTIVE: adiponectin is an adipocyte-derived hormone with anti-obesity and anti-diabetic properties. However, higher circulating adiponectin levels are related to poor muscle function and physical disability, which suggests a potential link between adiponectin and risk of falls. Nevertheless, no direct association between circulating adiponectin levels and incident fall risk has been reported. Therefore, this study aimed to investigate the relationship between serum adiponectin levels and incident falls in a population of middle-aged and older adults. <br><br>DESIGN: a prospective cohort study. SETTING: Oroshisho Center in Sendai City, Japan. SUBJECTS: Japanese adults who were ≥45 years old (n= 430). MEASUREMENTS: serum adiponectin levels were measured at baseline, and the subjects were divided into sex-specific tertiles. Data regarding a history of falls were collected via participant recall using a self-reported questionnaire. Incident falls were defined as falls that were experienced by people without a history of falls at baseline. <br><br>RESULTS: during the 2-year follow-up, 15.6% (67/430) of the subjects experienced an incident fall. In the univariate logistic regression analysis, incident falls were significantly more frequent across the increasing sex-specific serum adiponectin tertiles (Pfor trend = 0.008). Adjusted odds ratios (95% confidence interval) for incident falls were 2.31 (1.07-4.98) in the middle tertile and 3.61 (1.63-7.99) in the highest tertile; this risk was significantly higher than that for the lowest adiponectin tertile (Pfor trend = 0.002). <br><br>CONCLUSIONS: the findings of this prospective cohort study indicate that higher serum adiponectin levels may be a predictor of incident falls.<br><br>© The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society.<p /> <p>Language: en</p>",
language="en",
issn="0002-0729",
doi="10.1093/ageing/afw043",
url="http://dx.doi.org/10.1093/ageing/afw043"
}