@article{ref1,
title="Structural neural correlates of impaired mobility and subsequent decline in executive functions: a 12-month prospective study",
journal="Experimental gerontology",
year="2016",
author="Hsu, Chun Liang and Best, John R. and Chiu, Bryan K. and Nagamatsu, Lindsay S. and Voss, Michelle W. and Handy, Todd C. and Bolandzadeh, Niousha and Liu-Ambrose, Teresa",
volume="80",
number="",
pages="27-35",
abstract="Impaired mobility, such as falls, may be an early biomarker of subsequent cognitive decline and is associated with subclinical alterations in both brain structure and function. In this 12-month prospective study, we examined whether there are volumetric differences in gray matter and subcortical regions, as well as cerebral white matter, between older fallers and non-fallers. In addition, we assessed whether these baseline volumetric differences are associated with changes in cognitive function over 12months. A total of 66 community-dwelling older adults were recruited and categorized by their falls status. Magnetic resonance imaging occurred at baseline and participants' physical and cognitive performances were assessed at baseline and 12-months. At baseline, fallers showed significantly lower volumes in gray matter, subcortical regions, and cerebral white matter compared with non-fallers. Notably, fallers had significantly lower left lateral orbitofrontal white matter volume. Moreover, lower left lateral orbitofrontal white matter volume at baseline was associated with greater decline in set-shifting performance over 12months. Our data suggest that falls may indicate subclinical alterations in regional brain volume that are associated with subsequent decline in executive functions.<br><br>Copyright © 2015. Published by Elsevier Inc.<p /> <p>Language: en</p>",
language="en",
issn="0531-5565",
doi="10.1016/j.exger.2016.04.001",
url="http://dx.doi.org/10.1016/j.exger.2016.04.001"
}