@article{ref1,
title="Decreased regional gray matter volume in suicide attempters compared to suicide non-attempters with major depressive disorders",
journal="Comprehensive psychiatry",
year="2016",
author="Lee, Yu Jin and Kim, Soohyun and Gwak, Ah Reum and Kim, Seog Ju and Kang, Seung-Gul and Na, Kyoung-Sae and Son, Young-Don and Park, Juhyun",
volume="67",
number="",
pages="59-65",
abstract="OBJECTIVE: This study investigated regional gray matter (GM) volume differences between suicide attempters and suicide non-attempters with major depressive disorder (MDD) and their relationship with psychological risk factors for suicidality. <br><br>METHODS: MDD patients with and without a suicide attempt history (n=19 in each group) participated. The Hamilton Depression Rating Scale, Clinical Global Impression (severity subscale), Scale for Suicide Ideation (SSI), Risk-Rescue Rating (RRR), Beck Hopelessness Scale (BHS), Barrett Impulsivity Scale, Eysenck Personality Questionnaire, and Ways of Coping Checklist (WCCL) were administered. T1-weighted structural magnetic resonance imaging scans were acquired to evaluate changes in GM volume. Voxel-based morphometry was performed using the SPM 8 software package. Two-sample t-tests were used during second-level group comparison analysis; partial correlation analysis controlling for gender and age identified associations between regional GM volume and psychological measures. <br><br>RESULTS: Suicide attempters exhibited significantly decreased GM volume in the left angular gyrus (p<0.001, uncorrected) and right cerebellum (p<0.001, uncorrected). GM volume in the left angular gyrus was inversely correlated with BHS scores (r=-0.55, p<0.01) and positively correlated with the Seeking Social Support subscale of the WCCL (r=0.43, p<0.01). <br><br>CONCLUSION: These findings provide evidence of a neural basis of suicidal behaviors in MDD. In particular, reduced GM volume in the left angular gyrus may be a neurobiological marker of suicidality in depressed patients.<br><br>Copyright © 2016 Elsevier Inc. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0010-440X",
doi="10.1016/j.comppsych.2016.02.013",
url="http://dx.doi.org/10.1016/j.comppsych.2016.02.013"
}