@article{ref1,
title="Toxicodynetics: a new discipline in clinical toxicology",
journal="Annales Pharmaceutiques Francaises",
year="2016",
author="Baud, F. J. and Houze, P. and Villa, A. and Borron, Stephen W. and Carli, P.",
volume="74",
number="3",
pages="173-189",
abstract="OBJECTIVES: Regarding the different disciplines that encompass the pharmacology and the toxicology, none is specifically dedicated to the description and analysis of the time-course of relevant toxic effects both in experimental and clinical studies. The lack of a discipline devoted to this major field in toxicology results in misconception and even in errors by clinicians. MATERIAL AND METHODS: Review of the basic different disciplines that encompass pharmacology toxicology and comparing with the description of the time-course of effects in conditions in which toxicological analysis was not performed or with limited analytical evidence. <br><br>RESULTS: Review of the literature clearly shows how misleading is the current extrapolation of toxicokinetic data to the description of the time-course of toxic effects. <br><br>CONCLUSION: A new discipline entitled toxicodynetics should be developed aiming at a more systematic description of the time-course of effects in acute human and experimental poisonings. Toxicodynetics might help emergency physicians in risk assessment when facing a poisoning and contribute to a better assessment of quality control of data collected by poison control centres. Toxicodynetics would also allow a quantitative approach to the clinical effects resulting from drug-drug interaction.<br><br>Copyright © 2016. Published by Elsevier Masson SAS.<p /> <p>Language: en</p>",
language="en",
issn="0003-4509",
doi="10.1016/j.pharma.2016.02.003",
url="http://dx.doi.org/10.1016/j.pharma.2016.02.003"
}