@article{ref1,
title="Evidence for an agitated-aggressive syndrome in early-onset psychosis correlated with antisocial personality disorder, forensic history, and substance use disorder",
journal="Schizophrenia Research",
year="2016",
author="Huber, Christian G. and Hochstrasser, Lisa and Meister, Klara and Schimmelmann, Benno G. and Lambert, Martin",
volume="175",
number="1-3",
pages="198-203",
abstract="OBJECTIVE: Agitation, aggression, and violence are increased in psychotic disorders. Additionally, an earlier age at onset may be associated with aggressive behavior. However, the relationship of age at onset, an agitated-aggressive syndrome as measured with the Positive And Negative Syndrome Scale for Schizophrenia - Excited Component (PANSS-EC), and its potential correlates in first-episode psychosis (FEP) has not been studied. <br><br>METHOD: This study assessed the association between age at onset, an agitated-aggressive syndrome, and its potential correlates in a prospective sample of 52 FEP patients with early-onset and adult-onset followed up for 12months. <br><br>RESULTS: Twenty-six patients conformed to the criteria of early-onset psychosis. Early age at onset was associated with antisocial personality disorder (p=0.004; φc=0.39), a history of legal involvement (p=0.005; φc=0.39), and higher rates of lifetime substance use disorder (SUD; p=0.002; φc=0.42). Early-onset patients had significantly higher PANSS-EC scores over the course of observation (F(1,44.4)=5.39; p=0.025; d=0.656), but no significant group differences emerged for the remaining PANSS subscores. PANSS-EC scores were correlated positively with antisocial personality disorder and forensic history at 6weeks, 3months, 6months, and 12months, and with lifetime substance use disorder at 3months and 6months. <br><br>CONCLUSIONS: Patients with early onset psychosis may have increased levels of agitation/aggressiveness, and, more likely, antisocial personality disorder, forensic history, and lifetime substance use disorder. These variables were linked to suicidality, aggressiveness, and involuntary treatment.<br><br>Copyright © 2016 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0920-9964",
doi="10.1016/j.schres.2016.04.027",
url="http://dx.doi.org/10.1016/j.schres.2016.04.027"
}