@article{ref1,
title="Increasing benzodiazepine prescriptions and overdose mortality in the United States, 1996-2013",
journal="American journal of public health",
year="2016",
author="Bachhuber, Marcus A. and Hennessy, Sean and Cunningham, Chinazo O. and Starrels, Joanna L.",
volume="106",
number="4",
pages="686-688",
abstract="OBJECTIVEs. To describe trends in benzodiazepine prescriptions and overdose mortality involving benzodiazepines among US adults.<br><br>METHODS. We examined data from the Medical Expenditure Panel Survey and multiple-cause-of-death data from the Centers for Disease Control and Prevention.<br><br>RESULTS. Between 1996 and 2013, the percentage of adults filling a benzodiazepine prescription increased from 4.1% (95% confidence interval [CI] = 3.8%, 4.5%) to 5.6% (95% CI = 5.2%, 6.1%), with an annual percent change of 2.5% (95% CI = 2.1%, 3.0%). The quantity of benzodiazepines filled increased from 1.1 (95% CI = 0.9, 1.2) to 3.6 (95% CI = 3.0, 4.2) kilogram lorazepam equivalents per 100 000 adults (annual percent change = 9.0%; 95% CI = 7.6%, 10.3%). The overdose death rate increased from 0.58 (95% CI = 0.55, 0.62) to 3.07 (95% CI = 2.99, 3.14) per 100 000 adults, with a plateau seen after 2010.<br><br>CONCLUSIONS. Benzodiazepine prescriptions and overdose mortality have increased considerably. Fatal overdoses involving benzodiazepines have plateaued overall; however, no evidence of decreases was found in any group. Interventions to reduce the use of benzodiazepines or improve their safety are needed.<p /> <p>Language: en</p>",
language="en",
issn="0090-0036",
doi="10.2105/AJPH.2016.303061",
url="http://dx.doi.org/10.2105/AJPH.2016.303061"
}