@article{ref1,
title="A European multicentre survey of impulse control behaviours in Parkinson's disease patients treated with short- and long-acting dopamine agonists",
journal="European journal of neurology",
year="2016",
author="Rizos, A. and Sauerbier, A. and Antonini, A. and Weintraub, D. and Martínez-Martín, P. and Kessel, B. and Henriksen, T. and Falup-Pecurariu, C. and Silverdale, M. and Durner, G. and Røkenes Karlsen, K. and Grilo, M. and Odin, P. and Chaudhuri, K. Ray",
volume="23",
number="8",
pages="1255-1261",
abstract="BACKGROUND AND PURPOSE: Impulse control disorders (ICDs) in Parkinson's disease (PD) are associated primarily with dopamine agonist (DA) use. Comparative surveys of clinical occurrence of impulse control behaviours on longer acting/transdermal DA therapy across age ranges are lacking. The aim of this study was to assess the occurrence of ICDs in PD patients across several European centres treated with short- or long-acting [ropinirole (ROP); pramipexole (PPX)] and transdermal [rotigotine skin patch (RTG)] DAs, based on clinical survey as part of routine clinical care. <br><br>METHODS: A survey based on medical records and clinical interviews of patients initiating or initiated on DA treatment (both short- and long-acting, and transdermal) across a broad range of disease stages and age groups was performed. <br><br>RESULTS: Four hundred and twenty-five cases were included [mean age 68.3 years (range 37-90), mean duration of disease 7.5 years (range 0-37)]. ICD frequencies (as assessed by clinical interview) were significantly lower with RTG (4.9%; P < 0.05) compared with any other assessed DAs except for prolonged release PPX (PPX-PR). The rate of ICDs for PPX-PR (6.6%) was significantly lower than for immediate release PPX (PPX-IR) (19.0%; P < 0.05). Discontinuation rates of DA therapy due to ICDs were low. <br><br>CONCLUSION: Our data suggest a relatively low rate of ICDs with long-acting or transdermal DAs, however these preliminary observational data need to be confirmed with prospective studies controlling for possible confounding factors.<br><br>© 2016 EAN.<p /> <p>Language: en</p>",
language="en",
issn="1351-5101",
doi="10.1111/ene.13034",
url="http://dx.doi.org/10.1111/ene.13034"
}