@article{ref1,
title="The synthesis and investigation of impurities found in clandestine laboratories: Baeyer-Villiger Route Part I; synthesis of P2P from benzaldehyde and methyl ethyl ketone",
journal="Forensic science international",
year="2016",
author="Doughty, David and Painter, Ben and Pigou, Paul E. and Johnston, Martin R.",
volume="263",
number="",
pages="55-66",
abstract="The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple &quot;fingerprint&quot; profiling. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK); a Baeyer-Villiger reaction; and ester hydrolysis. We have identified and selectively synthesised several impurities that may be used as route specific markers for this series of synthetic steps. Specifically these impurities are 3-methyl-4-phenyl-3-buten-2-one 3, 2-methyl-1,5-diphenylpenta-1,4-diene-3-one 9, 2-(methylamino)-3-methyl-4-phenyl-3-butene 16, 2-(Methylamino)-3-methyl-4-phenylbutane 17, and 1-(methylamino)-2-methyl-1,5-diphenylpenta-4-ene-3-one 22.<br><br>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0379-0738",
doi="10.1016/j.forsciint.2016.03.034",
url="http://dx.doi.org/10.1016/j.forsciint.2016.03.034"
}