@article{ref1,
title="FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression",
journal="Psychiatry research",
year="2016",
author="Bryushkova, Lyubov and Zai, Clement and Chen, Sheng and Pappa, Irene and Mileva, Viara and Tiemeier, Henning and Bakermans-Kranenburg, Marian and Kennedy, James L. and Beitchman, Joseph H.",
volume="242",
number="",
pages="277-280",
abstract="Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.<br><br>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2015.09.052",
url="http://dx.doi.org/10.1016/j.psychres.2015.09.052"
}