@article{ref1,
title="Counterfeit adderall containing aceclofenac from internet pharmacies",
journal="Journal of forensic sciences",
year="2016",
author="Gaudiano, Maria Cristina and Borioni, Anna and Antoniella, Eleonora and Valvo, Luisa",
volume="61",
number="4",
pages="1126-1130",
abstract="A nontargeted approach based on liquid chromatography equipped with a quadrupole time-of-flight mass detector (LC-MS Q-TOF) joined to nuclear magnetic resonance (NMR) analysis allowed rapid identification and quantification of the anti-inflammatory drug aceclofenac in illegal Adderall tablets. The largest chromatographic peak had m/z = 354.030 and m/z = 376.012 matching, respectively, the ionic structures (M + H)(+) and (M + Na)(+) of a molecule M. The accurate mass data generated the molecular formula C16 H13 Cl2 NO4. A screening of the pharmaceutical active substances having that molecular formula together with the MS/MS fragmentation pattern suggested aceclofenac. Aceclofenac structure was unambiguously confirmed by (1) H and (13) C NMR experiments. The aceclofenac content was 90 mg/tablet (RSD 2%) as detected by quantitative NMR. Information on the identity and content of illegal drugs is required for legal purposes; it supports in evaluating the effective impact on users safety, and it is useful for control laboratories using a targeted approach in their analytical activities.<br><br>© 2016 American Academy of Forensic Sciences.<p /> <p>Language: en</p>",
language="en",
issn="0022-1198",
doi="10.1111/1556-4029.13095",
url="http://dx.doi.org/10.1111/1556-4029.13095"
}